Nano Cancer Bombs And Mini Organs From MIT

Nano cancer-bombs and mini organs from MIT

Scientists at MIT have developed remote-controlled nano particles that, with the push of a button, can deliver drugs directly to a tumour. The same research director has also found a way to build tiny human "livers" just 500 micrometres across. This work should lead to more reliable toxicity testing for new drugs.

According to Geoff von Maltzahn, post-doctoral researcher at the Harvard-MIT division of health sciences & technology (HST), the nano particles are first persuaded to clump together, which makes it easier to track their progress through a patient's body. Then, drug molecules are attached to the clumps of nanoparticles with DNA tethers and the whole lot is injected into the patient.

The nanoparticles are then tracked with an MRI scanner (hence the clumping). When they get to their target they are pulsed with an electromagnetic field at between 350-400kHz. This is harmless to the human body, but melts the tether and releases the drugs exactly where they are needed.

The breakthrough rests on a property of the nanoparticles: superparamagnetism. This characteristic causes them to give off heat when they are exposed to a magnetic field. This heat breaks the connection with the DNA tether, and allows the system to deliver the drugs.

Using DNA as the tether has another advantage: it makes it possible to choose the EM frequency that will break the bond, since longer or differently arranged strands will have different melting points. This means one clump of nanoparticles can carry multiple doses of drugs to several sites. If each drug has differently tuned DNA tethers, doctors can use a different EM frequency to deliver each dose.

Cancer Cure May Be Available In Two Years

Cancer cure 'may be available in two years'

Cancer sufferers could be cured with injections of immune cells from other people within two years, scientists say.

US researchers have been given the go-ahead to give patients transfusions of “super strength” cancer-killing cells from donors.

Dr Zheng Cui, of the Wake Forest University School of Medicine, has shown in laboratory experiments that immune cells from some people can be almost 50 times more effective in fighting cancer than in others.

Dr Cui, whose work is highlighted in this week’s New Scientist magazine, has previously shown cells from mice found to be immune to cancer can be used to cure ordinary mice with tumours.

The work raises the prospect of using cancer-killing immune system cells called granulocytes from donors to significantly boost a cancer patient’s ability to fight their disease, and potentially cure them.

The US Food and Drug Administration (FDA) last week gave Dr Cui permission to inject super-strength granulocytes into 22 patients.

Dr Cui said: “Our hope is that this could be a cure. Our pre-clinical tests have been exceptionally successful.

“If this is half as effective in humans as it is in mice it could be that half of patients could be cured or at least given one to two years extra of high quality life.

“The technology needed to do this already exists, so if it works in humans we could save a lot of lives, and we could be doing so within two years.”